Abnormal brain metabolism on FDG-PET/CT is a common early finding in autoimmune encephalitis.

ABSTRACT:

Objective

To compare the rate of abnormal brain metabolism by FDG-PET/CT to other paraclinical findings and to describe brain metabolism patterns in autoimmune encephalitis (AE).

Methods

A retrospective review of clinical data and initial dedicated brain FDG-PET/CT studies for neurology inpatients with AE, per consensus criteria, treated at a single tertiary center over 123 months. Z-score maps of FDG-PET/CT were made using 3-dimensional stereotactic surface projections with comparison to age group-matched controls. Brain region mean Z-scores with magnitudes ≥2.00 were interpreted as significant. Comparisons were made to rates of abnormal initial brain MRI, abnormal initial EEG, and presence of intrathecal inflammation.

Results

Sixty-one patients with AE (32 seroposit

SUBMITTER: Probasco JC 

PROVIDER: S-EPMC5442608 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature