Chemical constituents from a Gynostemma laxum and their antioxidant and neuroprotective activities.

ABSTRACT:

Background

A few bioactivities of constituents from Gynostemma laxum, which has been collected in Vietnam, have been reported until now. There is no report about the effects of constituents from G. laxum although the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase-1 (HO-1) antioxidant defense system is involved in neuroprotection in the brain. Therefore, we investigated whether quercetin (2), benzoic acid (10) and their analogues (1, 3-9 and 11) from G. laxum have the antioxidant and neuroprotective activities and also their underlying mechanism.

Methods

To examine their neuroprotective and antioxidant activities, oxytosis, total oxidant scavenging capacity (TOSC), 2,7-dichlorofluoresce

SUBMITTER: Seo JY 

PROVIDER: S-EPMC5442659 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature