Does the placebo effect modulate drug bioavailability? Randomized cross-over studies of three drugs.

ABSTRACT:

Background

Medication effect is the sum of its drug, placebo, and drug*placebo interaction effects. It is conceivable that the interaction effect involves modulating drug bioavailability; it was previously observed that being aware of caffeine ingestion may prolong caffeine plasma half-life. This study was set to evaluate such concept using different drugs.

Methods

Balanced single-dose, two-period, two-group, cross-over design was used to compare the pharmacokinetics of oral cephalexin, ibuprofen, and paracetamol, each described by its name (overt) or as placebo (covert). Volunteers and study coordinators were deceived as to study aim. Drug concentrations were determined blindly by in-house, high performance liquid chromatography assays. Terminal-elimination half-life (t

SUBMITTER: Hammami MM 

PROVIDER: S-EPMC5442689 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature