Functional Human and Murine Tissue-Engineered Liver Is Generated from Adult Stem/Progenitor Cells.

ABSTRACT: Liver disease affects large numbers of patients, yet there are limited treatments available to replace absent or ineffective cellular function of this crucial organ. Donor scarcity and the necessity for immunosuppression limit one effective therapy, orthotopic liver transplantation. But in some conditions such as inborn errors of metabolism or transient states of liver insufficiency, patients may be salvaged by providing partial quantities of functional liver tissue. After transplanting multicellular liver organoid units composed of a heterogeneous cellular population that includes adult stem and progenitor cells, both mouse and human tissue-engineered liver (TELi) form in vivo. TELi contains normal liver components such as hepatocytes with albumin expression, CK19-expressing bile ducts an

SUBMITTER: Mavila N 

PROVIDER: S-EPMC5442734 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature