Pepsinogen C expression, regulation and its relationship with cancer.

ABSTRACT: Pepsinogen C (PGC) belongs to the aspartic protease family and is secreted by gastric chief cells. PGC could be activated to pepsin C and digests polypeptides and amino acids, but as a zymogen PGC's functions is unclear. In normal physiological conditions, PGC is initially detected in the late embryonic stage and is mainly expressed in gastric mucosa. The in situ expression of PGC in gastric mucosa is decreased considerably in the process of superficial gastritis → atrophic gastritis → gastric cancer (GC), proving that PGC is a comparatively ideal negative marker of GC. Serum PGC, and PGA levels and the PGA/PGC ratio have satisfactory sensitivity, specificity and price-quality ratio for predicting high GC risk. Ectopic PGC expression is significantly increased in prostate cancer, breast ca

SUBMITTER: Shen S 

PROVIDER: S-EPMC5442862 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature