Immature myeloid cells are critical for enhancing bone fracture healing through angiogenic cascade.

ABSTRACT: Bone fractures heal with overlapping phases of inflammation, cell proliferation, and bone remodeling. Osteogenesis and angiogenesis work in concert to control many stages of this process, and when one is impaired it leads to failure of bone healing, termed a nonunion. During fracture repair, there is an infiltration of immune cells at the fracture site that not only mediate the inflammatory responses, but we hypothesize they also exert influence on neovasculature. Thus, further understanding the effects of immune cell participation throughout fracture healing will reveal additional knowledge as to why some fractures heal while others form nonunions, and lead to development of novel therapeutics modulating immune cells, to increase fracture healing and prevent nonunions. Using novel femoral

SUBMITTER: Levy S 

PROVIDER: S-EPMC5443259 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature