Randomized Controlled Trial of a MUFA or Fiber-Rich Diet on Hepatic Fat in Prediabetes.

ABSTRACT:

Context

Increased prevalence of type 2 diabetes mellitus and prediabetes worldwide is attributed in part to an unhealthy diet.

Objective

To evaluate whether 12 weeks of high monounsaturated fatty acid (MUFA) or fiber-rich weight-maintenance diet lowers hepatic fat and improves glucose tolerance in people with prediabetes.

Design

Subjects underwent a [6, 6-2H2]-labeled 75-g oral glucose tolerance test to estimate hepatic insulin sensitivity and liver fat fraction (LFF) using magnetic resonance spectroscopy before and after intervention.

Setting

Mayo Clinic Clinical Research Trials Unit.

Participants

43 subjects with prediabetes.

Intervention

Subjects were randomized into three isocaloric weight-maintaining diets containing MUFA (olive oil), extra f

SUBMITTER: Errazuriz I 

PROVIDER: S-EPMC5443322 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature