Preconception Low-Dose Aspirin Restores Diminished Pregnancy and Live Birth Rates in Women With Low-Grade Inflammation: A Secondary Analysis of a Randomized Trial.

ABSTRACT:

Context

Inflammation is linked to causes of infertility. Low-dose aspirin (LDA) may improve reproductive success in women with chronic, low-grade inflammation.

Objective

To investigate the effect of preconception-initiated LDA on pregnancy rate, pregnancy loss, live birth rate, and inflammation during pregnancy.

Design

Stratified secondary analysis of a multicenter, block-randomized, double-blind, placebo-controlled trial.

Setting

Four US academic medical centers, 2007 to 2012.

Participants

Healthy women aged 18 to 40 years (N = 1228) with one to two prior pregnancy losses actively attempting to conceive.

Intervention

Preconception-initiated, daily LDA (81 mg) or matching placebo taken up to six menstrual cycles attempting pregnancy and through 36

SUBMITTER: Sjaarda LA 

PROVIDER: S-EPMC5443323 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature