Thyroid Status and Mortality in a Prospective Hemodialysis Cohort.

ABSTRACT:

Context and objective

Compared with the general population, hemodialysis patients have a substantially higher risk of hypothyroidism, as defined by an elevated serum thyrotropin (TSH) level, and cardiovascular mortality. Whereas an elevated TSH is associated with cardiovascular disease and death in the general population, associations among dialysis patients have been inconsistent.

Design, setting, participants, and main outcome

We examined 541 hemodialysis patients from 17 southern California dialysis centers in the prospective Hypothyroidism, Cardiovascular Health, and Survival study who underwent protocolized measurement of repeated serum TSH levels every 6 months from 2013 to 2015. Associations between TSH tertiles (<1.28, 1.28 to <2.14, and 2.14 to 86.7 mIU/L) and morta

SUBMITTER: Rhee CM 

PROVIDER: S-EPMC5443328 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature