Early embryo mortality in natural human reproduction: What the data say.

ABSTRACT: How many human embryos die between fertilisation and birth under natural conditions? It is widely accepted that natural human embryo mortality is high, particularly during the first weeks after fertilisation, with total prenatal losses of 70% and higher frequently claimed. However, the first external sign of pregnancy occurs two weeks after fertilisation with a missed menstrual period, and establishing the fate of embryos before this is challenging. Calculations are additionally hampered by a lack of data on the efficiency of fertilisation under natural conditions. Four distinct sources are used to justify quantitative claims regarding embryo loss: (i) a hypothesis published by Roberts & Lowe in TheLancet  is widely cited but has no practical quantitative value; (ii) life tab

SUBMITTER: Jarvis GE 

PROVIDER: S-EPMC5443340 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature