Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up.

ABSTRACT:

Rationale

The evidence supporting an association between traffic-related air pollution exposure and incident childhood asthma is inconsistent and may depend on genetic factors.

Objectives

To identify gene-environment interaction effects on childhood asthma using genome-wide single-nucleotide polymorphism (SNP) data and air pollution exposure. Identified loci were further analyzed at epigenetic and transcriptomic levels.

Methods

We used land use regression models to estimate individual air pollution exposure (represented by outdoor NO₂ levels) at the birth address and performed a genome-wide interaction study for doctors' diagnoses of asthma up to 8 years in three European birth cohorts (n = 1,534) with look-up for interaction in two separate North American

SUBMITTER: Gref A 

PROVIDER: S-EPMC5443897 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature