Tat-haFGF_14-154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway.

ABSTRACT: Acid fibroblast growth factor (aFGF) has shown neuroprotection in Alzheimer's disease (AD) models in previous studies, yet its mechanism is still uncertain. Here we report that the efficacy of Tat-haFGF_14-154 is markedly increased when loaded cationic liposomes for intranasal delivery are intranasally administered to APP/PS1 mice. Our results demonstrated that liposomal Tat-haFGF_14-154 treatment significantly ameliorated behavioral deficits, relieved brain Aβ burden, and increased the expression and activity of disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) in the brain. Tat-haFGF_14-154 antagonized Aβ_1-42-induced cell death and structural damage in rat primary neurons in an ADAM10-dependent manner, which, in turn, was pro

SUBMITTER: Meng T 

PROVIDER: S-EPMC5443968 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature