Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders.

ABSTRACT:

Objective

Identification of additional regulatory factors involved in the onset of obesity is important to understand the mechanisms underlying this prevailing disease and its associated metabolic disorders and to develop therapeutic strategies. Through isolation and analysis of a mutant, we aimed to uncover the function of a Ras-GAP gene, Rasal2 (Ras protein activator like 2), in the development of obesity and related metabolic disorders and to obtain valuable insights regarding the mechanism underlying the function.

Methods

An obesity-based genetic screen was performed to identify an insertional mutation that disrupts the expression of Rasal2 (Rasal2^PB/PB mice). Important metabolic parameters, such as fat mass and glucose tolerance, were measured i

SUBMITTER: Zhu X 

PROVIDER: S-EPMC5444017 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature