FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue.

ABSTRACT:

Objective

Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates metabolic homeostasis. Previous work has suggested that impairment of FGF21 signaling in adipose tissue may occur through downregulation of the obligate FGF21 co-receptor, β-klotho, which leads to "FGF21 resistance" during the onset of diet-induced obesity. Here, we sought to determine whether maintenance of β-klotho expression in adipose tissue prevents FGF21 resistance and whether other mechanisms also contribute to FGF21 resistance in vivo.

Methods

We generated adipose-specific β-klotho transgenic mice to determine whether maintenance of β-klotho expression in adipose tissue prevents FGF21 resistance in vivo.

Results

β-klotho protein levels are markedly decreased in white adipose t

SUBMITTER: Markan KR 

PROVIDER: S-EPMC5444074 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature