Insulin controls food intake and energy balance via NPY neurons.

ABSTRACT:

Objectives

Insulin signaling in the brain has been implicated in the control of satiety, glucose homeostasis and energy balance. However, insulin signaling is dispensable in energy homeostasis controlling AgRP or POMC neurons and it is unclear which other neurons regulate these effects. Here we describe an ancient insulin/NPY neuronal network that governs energy homeostasis across phyla.

Methods

To address the role of insulin action specifically in NPY neurons, we generated a variety of models by selectively removing insulin signaling in NPY neurons in flies and mice and testing the consequences on energy homeostasis.

Results

By specifically targeting the insulin receptor in both fly and mouse NPY expressing neurons, we found NPY-specific insulin signaling controls fo

SUBMITTER: Loh K 

PROVIDER: S-EPMC5444095 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature