Certainty of genuine treatment increases drug responses among intellectually disabled patients.

ABSTRACT:

Objective

To determine the placebo component of treatment responses in patients with intellectual disability (ID).

Methods

A statistical meta-analysis comparing bias-corrected effect sizes (Hedges g) of drug responses in open-label vs placebo-controlled clinical trials was performed, as these trial types represent different certainty of receiving genuine treatment (100% vs 50%). Studies in fragile X, Down, Prader-Willi, and Williams syndrome published before June 2015 were considered.

Results

Seventeen open-label trials (n = 261, 65% male; mean age 23.6 years; mean trial duration 38 weeks) and 22 placebo-controlled trials (n = 721, 62% male; mean age 17.1 years; mean trial duration 35 weeks) were included. The overall effect size from pre to post treatment in o

SUBMITTER: Jensen KB 

PROVIDER: S-EPMC5444309 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature