Fetal Pathology of Neural Tube Defects - An Overview of 68 Cases.

ABSTRACT:

Introduction

The prevalence of neural tube defects worldwide is 1 - 2 per 1000 neonates. Neural tube defects result from a disturbance of neurulation in the 3rd or 4th week of development and thus represent the earliest manifestation of organ malformation. Neural tube defects (NTD) are classified into cranial dysraphism leading to anencephaly or meningoencephalocele and spinal dysraphism with or without meningomyelocele. In isolated form they have multifactorial causes, and the empirical risk of recurrence in Central Europe is 2%. As associated malformations they tend to occur sporadically, and in monogenic syndromes they follow Mendelian inheritance patterns with a high risk of recurrence.

Patients

Autopsies were performed on 68 fetuses following a prenatal diagnosis of NTD

SUBMITTER: Schoner K 

PROVIDER: S-EPMC5444532 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature