A theoretical framework for determining cerebral vascular function and heterogeneity from dynamic susceptibility contrast MRI.

ABSTRACT: Mapping the complex heterogeneity of vascular tissue in the brain is important for understanding cerebrovascular disease. In this translational study, we build on previous work using vessel architectural imaging (VAI) and present a theoretical framework for determining cerebral vascular function and heterogeneity from dynamic susceptibility contrast magnetic resonance imaging (MRI). Our tissue model covers realistic structural architectures for vessel branching and orientations, as well as a range of hemodynamic scenarios for blood flow, capillary transit times and oxygenation. In a typical image voxel, our findings show that the apparent MRI relaxation rates are independent of the mean vessel orientation and that the vortex area, a VAI-based parameter, is determined by the relative oxygen

SUBMITTER: Digernes I 

PROVIDER: S-EPMC5444554 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature