Development and validation of nomograms for predicting survival in patients with non-metastatic colorectal cancer.

ABSTRACT:

Background

This study aimed to develop nomograms for predicting survival in patients with non-metastatic colorectal cancer (CRC).

Results

On multivariate analyses of the derivation set, the nomograms for OS and CSS shared common significant prognostic factors: age, first-degree relative cancer history, differentiation grade, vessels/nerves invasion, TNM stage, CEA, CA19-9 and PNI. The nomograms displayed good accuracy in predicting OS and CSS, with C-indexes of 0.75 and 0.76, respectively. The calibration plots also showed an excellent agreement between the predicted and observed survival probabilities. Furthermore, the predictive accuracy of the nomograms was confirmed in the validation set, with C-indexes of 0.79 and 0.83 for OS and CSS, respectively.

Materials and meth

SUBMITTER: Jiang H 

PROVIDER: S-EPMC5444709 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature