Local Inflammatory Cues Regulate Differentiation and Persistence of CD8⁺ Tissue-Resident Memory T Cells.

ABSTRACT: Many pathogens initiate infection at mucosal surfaces, and tissue-resident memory T (Trm) cells play an important role in protective immunity, yet the tissue-specific signals that regulate Trm differentiation are poorly defined. During Yersinia infection, CD8⁺ T cell recruitment to areas of inflammation within the intestine is required for differentiation of the CD103^-CD69⁺ Trm subset. Intestinal proinflammatory microenvironments have elevated interferon (IFN)-β and interleukin-12 (IL-12), which regulated Trm markers, including CD103. Type I interferon-receptor- or IL-12-receptor-deficient T cells functioned similarly to wild-type (WT) cells during infection; however, the inability of T cells to respond to inflammation resulted in defective differentiation

SUBMITTER: Bergsbaken T 

PROVIDER: S-EPMC5444811 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature