Revisiting the discriminatory accuracy of traditional risk factors in preeclampsia screening.

ABSTRACT: BACKGROUND:Preeclampsia (PE) is associated with a high risk of perinatal morbidity and mortality. However, there is no consensus in the definition of high-risk women. AIM:To question current definition of high PE risk and propose a definition that considers individual heterogeneity to improves risk classification. METHODS:A stratified analysis by parity was conducted using the Swedish Birth Register between 2002-2010 including 626.600 pregnancies. The discriminatory accuracy (DA) of traditional definitions of high-risk women was compared with a new definition based on 1) specific combinations of individual variables and 2) a centile cut-off of the probability of PE predicted by a multiple logistic regression model. RESULTS:None of the classical risk-factors alone reached an acceptable DA.

SUBMITTER: Rodriguez-Lopez M 

PROVIDER: S-EPMC5444844 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature