The RicAFT (YmcA-YlbF-YaaT) complex carries two [4Fe-4S]²⁺ clusters and may respond to redox changes.

ABSTRACT: During times of environmental insult, Bacillus subtilis undergoes developmental changes leading to biofilm formation, sporulation and competence. Each of these states is regulated in part by the phosphorylated form of the master response regulator Spo0A (Spo0A∼P). The phosphorylation state of Spo0A is controlled by a multi-component phosphorelay. RicA, RicF and RicT (previously YmcA, YlbF and YaaT) have been shown to be important regulatory proteins for multiple developmental fates. These proteins directly interact and form a stable complex, which has been proposed to accelerate the phosphorelay. Indeed, this complex is sufficient to stimulate the rate of phosphotransfer amongst the phosphorelay proteins in vitro. In this study, we demonstrate that two [4Fe-4S]²⁺ clusters can be

SUBMITTER: Tanner AW 

PROVIDER: S-EPMC5444954 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature