Emergent role of the fractalkine axis in dissemination of peritoneal metastasis from epithelial ovarian carcinoma.

ABSTRACT: Epithelial ovarian carcinoma is the most common cause of death from gynecologic cancers largely due to advanced, relapsed and chemotherapy-resistant peritoneal metastasis, which is refractory to the currently used treatment approaches. Mechanisms supporting advanced and relapsed peritoneal metastasis are largely unknown, precluding development of more effective targeted therapies. In this study, we investigated the function of a potentially targetable fractalkine axis in the formation and the development of advanced and relapsed peritoneal metastasis and its impact on patients' outcomes. Our mouse model studies support a role for the fractalkine receptor (CX₃CR1) in the initiation of peritoneal adhesion important for recolonization of relapsed peritoneal metastasis. We show that

SUBMITTER: Gurler Main H 

PROVIDER: S-EPMC5444995 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature