Quantitative analysis of dynamic ¹⁸F-FDG PET/CT for measurement of lung inflammation.

ABSTRACT:

Background

An inflammatory reaction in the airways and lung parenchyma, comprised mainly of neutrophils and alveolar macrophages, is present in some patients with chronic obstructive pulmonary disease (COPD). Thoracic fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET) has been proposed as a promising imaging biomarker to assess this inflammation. We sought to introduce a fully quantitative analysis method and compare this with previously published studies based on the Patlak approach using a dataset comprising ¹⁸F-FDG PET scans from COPD subjects with elevated circulating inflammatory markers (fibrinogen) and matched healthy volunteers (HV). Dynamic ¹⁸F-FDG PET scans were obtained for high-fibrinogen (>2.8 g/l) COPD subjects (N = 10) an

SUBMITTER: Coello C 

PROVIDER: S-EPMC5445063 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature