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Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis.

ABSTRACT: The transcription factor forkhead box protein 3 (FOXP3) is an essential molecular marker of regulatory T cell (Treg) development in different microenvironments. Tregs are cells specialized in the suppression of inadequate immune responses and the maintenance of homeostatic tolerance. Studies have addressed and elucidated the role played by FOXP3 and Treg in countless autoimmune and infectious diseases as well as in more specific cases, such as cancer. Within this context, the present article reviews aspects of the immunoregulatory profile of FOXP3 and Treg in the management of immune homeostasis, including issues relating to pathology as well as immune tolerance.

SUBMITTER: Pereira LMS 

PROVIDER: S-EPMC5445144 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis.

Pereira Leonn Mendes Soares LMS   Gomes Samara Tatielle Monteiro STM   Ishak Ricardo R   Vallinoto Antonio Carlos Rosário ACR  

Frontiers in immunology 20170526

The transcription factor forkhead box protein 3 (FOXP3) is an essential molecular marker of regulatory T cell (Treg) development in different microenvironments. Tregs are cells specialized in the suppression of inadequate immune responses and the maintenance of homeostatic tolerance. Studies have addressed and elucidated the role played by FOXP3 and Treg in countless autoimmune and infectious diseases as well as in more specific cases, such as cancer. Within this context, the present article rev  ...[more]

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