Euvolemic hyponatremia in cancer patients. Report of the Hyponatremia Registry: an observational multicenter international study.

ABSTRACT:

Purpose

Hyponatremia secondary to SIADH is frequent in cancer patients and potentially deleterious. The aim of this sub-analysis of the Hyponatremia Registry database is to analyze current diagnostic and therapeutic management practices in cancer patients with SIADH.

Methods

We analyzed 358 cancer patients who had serum sodium concentration ([Na⁺]) ≤ 130 mEq/L and a clinical diagnosis of SIADH from 225 sites in the USA and EU.

Results

Precise diagnostic testing was performed in only 46%. Almost 12% of all patients did not receive any hyponatremia treatment. The most frequent therapies were fluid restriction (20%), isotonic saline (14%), fluid restriction/isotonic saline (7%), tolvaptan (8%), and salt tablets (7%). Hypertonic saline was used in less than 3%.

SUBMITTER: Burst V 

PROVIDER: S-EPMC5445151 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature