Characteristic Changes in Decidual Gene Expression Signature in Spontaneous Term Parturition.

ABSTRACT:

Background

The decidua has been implicated in the "terminal pathway" of human term parturition, which is characterized by the activation of pro-inflammatory pathways in gestational tissues. However, the transcriptomic changes in the decidua leading to terminal pathway activation have not been systematically explored. This study aimed to compare the decidual expression of developmental signaling and inflammation-related genes before and after spontaneous term labor in order to reveal their involvement in this process.

Methods

Chorioamniotic membranes were obtained from normal pregnant women who delivered at term with spontaneous labor (TIL, n = 14) or without labor (TNL, n = 15). Decidual cells were isolated from snap-frozen chorioamniotic membranes with laser microdissection

SUBMITTER: El-Azzamy H 

PROVIDER: S-EPMC5445200 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature