Long-lasting effect of obesity on skeletal muscle transcriptome.

ABSTRACT:

Background

Reduced physical activity and increased intake of calorically-dense diets are the main risk factors for obesity, glucose intolerance, and type 2 diabetes. Chronic overnutrition and hyperglycemia can alter gene expression, contributing to long-term obesity complications. While caloric restriction can reduce obesity and glucose intolerance, it is currently unknown whether it can effectively reprogram transcriptome to a pre-obesity level. The present study addressed this question by the preliminary examination of the transcriptional dynamics in skeletal muscle after exposure to overnutrition and following caloric restriction.

Results

Six male rhesus macaques of 12-13 years of age consumed a high-fat western-style diet for 6 months and then were calorically restricted

SUBMITTER: Messaoudi I 

PROVIDER: S-EPMC5445270 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature