Genetic diversity of Mycobacterium tuberculosis isolates from Tochigi prefecture, a local region of Japan.

ABSTRACT:

Background

Foreign-born patients with tuberculosis (TB) may introduce globally disseminated isolates of Mycobacterium tuberculosis into large cities in Japan. The risk of dissemination of these isolates into local regions, however, has not been determined. This study analyzed the molecular epidemiology of M. tuberculosis isolates obtained from TB patients living in a local region of Japan.

Methods

Whole genome sequences of 169 M. tuberculosis isolates, obtained from 148 Japanese-born and 21 foreign-born patients living in Tochigi, Japan, were analyzed using the Comprehensive analysis server for the Mycobacterium t u b erculosis complex (CASTB).

Results

The 169 isolates were clustered into four clades; Lineage 2 (111 isolates 65.7%), Lineage 4 (43 isolates, 25.4%), Lin

SUBMITTER: Mizukoshi F 

PROVIDER: S-EPMC5445273 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature