Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) is associated with increased intestinal permeability, which involves paracellular passage regulated through tight junctions (TJ). The aim of the study was to investigate single nucleotide polymorphisms (SNP) located in genes encoding interacting TJ proteins and corresponding expressions, in relation to IBD.

Methods

Allelic associations between TJ-related genes (F11R, MAGI1, MAGI2, MAGI3, PARD3, PTEN, and TJP1) and IBD, Crohn's disease (CD), or ulcerative colitis (UC) were investigated. PTPN22 was included since it's located in the same genetic region as MAGI3. Gene expression levels were investigated in relation to genotype, inflammatory status, phenotype, and medical treatment.

Results

The two strongest allelic associations

SUBMITTER: Noren E 

PROVIDER: S-EPMC5445404 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature