Whole genome sequencing reveals within-host genetic changes in paired meningococcal carriage isolates from Ethiopia.

ABSTRACT:

Background

Meningococcal colonization is a prerequisite for transmission and disease, but the bacterium only very infrequently causes disease while asymptomatic carriage is common. Carriage is highly dynamic, showing a great variety across time and space within and across populations, but also within individuals. The understanding of genetic changes in the meningococcus during carriage, when the bacteria resides in its natural niche, is important for understanding not only the carriage state, but the dynamics of the entire meningococcal population.

Results

Paired meningococcal isolates, obtained from 50 asymptomatic carriers about 2 months apart were analyzed with whole genome sequencing (WGS). Phylogenetic analysis revealed that most paired isolates from the same individual

SUBMITTER: Barnes GK 

PROVIDER: S-EPMC5445459 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature