Pregnancy-induced gene expression changes in vivo among women with rheumatoid arthritis: a pilot study.

ABSTRACT:

Background

Little is known about gene expression changes induced by pregnancy in women with rheumatoid arthritis (RA) and healthy women because the few studies previously conducted did not have pre-pregnancy samples available as baseline. We have established a cohort of women with RA and healthy women followed prospectively from a pre-pregnancy baseline. In this study, we tested the hypothesis that pregnancy-induced changes in gene expression among women with RA who improve during pregnancy (pregDAS_improved) overlap substantially with changes observed among healthy women and differ from changes observed among women with RA who worsen during pregnancy (pregDAS_worse).

Methods

Global gene expression profiles were generated by RNA sequencing (RNA-seq) from

SUBMITTER: Goin DE 

PROVIDER: S-EPMC5445464 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature