Characterizing the roles of changing population size and selection on the evolution of flux control in metabolic pathways.

ABSTRACT:

Background

Understanding the genotype-phenotype map is fundamental to our understanding of genomes. Genes do not function independently, but rather as part of networks or pathways. In the case of metabolic pathways, flux through the pathway is an important next layer of biological organization up from the individual gene or protein. Flux control in metabolic pathways, reflecting the importance of mutation to individual enzyme genes, may be evolutionarily variable due to the role of mutation-selection-drift balance. The evolutionary stability of rate limiting steps and the patterns of inter-molecular co-evolution were evaluated in a simulated pathway with a system out of equilibrium due to fluctuating selection, population size, or positive directional selection, to contrast with th

SUBMITTER: Orlenko A 

PROVIDER: S-EPMC5445498 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature