The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish.

ABSTRACT: Hedgehog signaling is required for many aspects of development in vertebrates and invertebrates. Misregulation of the Hedgehog pathway causes developmental abnormalities and has been implicated in certain types of cancer. Large-scale genetic screens in zebrafish have identified a group of mutations, termed you-class mutations, that share common defects in somite shape and in most cases disrupt Hedgehog signaling. These mutant embryos exhibit U-shaped somites characteristic of defects in slow muscle development. In addition, Hedgehog pathway mutations disrupt spinal cord patterning. We report the positional cloning of you, one of the original you-class mutations, and show that it is required for Hedgehog signaling in the development of slow muscle and in the specification of ventral fates i

SUBMITTER: Woods IG 

PROVIDER: S-EPMC544551 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature