Inter-personal diversity and temporal dynamics of dental, tongue, and salivary microbiota in the healthy oral cavity.

ABSTRACT: Oral microbes form a complex and dynamic biofilm community, which is subjected to daily host and environmental challenges. Dysbiosis of the oral biofilm is correlated with local and distal infections and postulating a baseline for the healthy core oral microbiota provides an opportunity to examine such shifts during the onset and recurrence of disease. Here we quantified the daily, weekly, and monthly variability of the oral microbiome by sequencing the largest oral microbiota time-series to date, covering multiple oral sites in ten healthy individuals. Temporal dynamics of salivary, dental, and tongue consortia were examined by high-throughput 16S rRNA gene sequencing over 90 days, with four individuals sampled additionally 1 year later. Distinct communities were observed between dental,

SUBMITTER: Hall MW 

PROVIDER: S-EPMC5445578 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature