The product of the split ends gene is required for the maintenance of positional information during Drosophila development.

ABSTRACT:

Background

The Drosophila split ends (spen) gene encodes a large nuclear protein containing three RNP-type RNA binding motifs, and a conserved transcriptional co-repressor-interacting domain at the C-terminus. Genetic analyses indicate that spen interacts with pathways that regulate the function of Hox proteins, the response to various signaling cascades and cell cycle control. Although spen mutants affect only a small subset of morphological structures in embryos, it has been difficult to find a common theme in spen mutant structural alterations, or in the interactions of spen with known signaling pathways.

Results

By generating clones of spen mutant cells in wing imaginal discs, we show that spen function is required for the correct formation and positioning of veins and m

SUBMITTER: Mace K 

PROVIDER: S-EPMC544560 | biostudies-literature | 2004 Dec

REPOSITORIES: biostudies-literature