Monocyte Siglec-14 expression is upregulated in patients with systemic lupus erythematosus and correlates with lupus disease activity.

ABSTRACT:

Objective

Siglecs are sialic acid-binding immunoglobulin-like lectins expressed on the surface of immune cells, which participate in the discrimination of self and non-self. We investigated myeloid CD33-related Siglec expression in a cohort of patients with SLE.

Methods

Cell surface expression of Siglec-5/14, Siglec-9 and Siglec-10 on peripheral myeloid subsets were analysed from 39 SLE patients using flow cytometry. Genotyping of the Siglec-5/14 locus was also performed. Clinical markers of SLE disease activity, including SLEDAI, serum complement concentrations and serum autoantibodies, were assessed and correlated with Siglec levels.

Results

Siglec-14 expression on SLE monocytes (median = 518, interquartile range: 411) was significantly higher when compared with hea

SUBMITTER: Thornhill SI 

PROVIDER: S-EPMC5445601 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature