Meta-analysis of host response networks identifies a common core in tuberculosis.

ABSTRACT: Tuberculosis remains a major global health challenge worldwide, causing more than a million deaths annually. To determine newer methods for detecting and combating the disease, it is necessary to characterise global host responses to infection. Several high throughput omics studies have provided a rich resource including a list of several genes differentially regulated in tuberculosis. An integrated analysis of these studies is necessary to identify a unified response to the infection. Such data integration is met with several challenges owing to platform dependency, patient heterogeneity, and variability in the extent of infection, resulting in little overlap among different datasets. Network-based approaches offer newer alternatives to integrate and compare diverse data. In this s

SUBMITTER: Sambarey A 

PROVIDER: S-EPMC5445610 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature