Integrating personalized gene expression profiles into predictive disease-associated gene pools.

ABSTRACT: Gene expression data are routinely used to identify genes that on average exhibit different expression levels between a case and a control group. Yet, very few of such differentially expressed genes are detectably perturbed in individual patients. Here, we develop a framework to construct personalized perturbation profiles for individual subjects, identifying the set of genes that are significantly perturbed in each individual. This allows us to characterize the heterogeneity of the molecular manifestations of complex diseases by quantifying the expression-level similarities and differences among patients with the same phenotype. We show that despite the high heterogeneity of the individual perturbation profiles, patients with asthma, Parkinson and Huntington's disease share

SUBMITTER: Menche J 

PROVIDER: S-EPMC5445628 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature