Very-long-chain ω-3 fatty acid supplements and adipose tissue functions: a randomized controlled trial.

ABSTRACT: Background: Increased omega-3 (n-3) fatty acid consumption is reported to benefit patients with metabolic syndrome, possibly due to improved adipose tissue function.Objective: We tested the effects of high-dose, very-long-chain ω-3 fatty acids on adipose tissue inflammation and insulin regulation of lipolysis.Design: A double-blind, placebo-controlled study compared 6 mo of 3.9 g eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)/d (4.2 g total ω-3/d; n = 12) with a placebo (4.2 g oleate/d; n = 9) in insulin-resistant adults. Before and after treatment, the volunteers underwent adipose tissue biopsies to measure the total (CD68⁺), pro- (CD14⁺ = M1), and anti- (CD206⁺ = M2) inflammatory macrophages, crown-like struc

SUBMITTER: Hames KC 

PROVIDER: S-EPMC5445674 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature