Intraoperative tranexamic acid is associated with postoperative stroke in patients undergoing cardiac surgery.

ABSTRACT:

Background

Stroke is a devastating and potentially preventable complication of cardiac surgery. Tranexamic acid (TXA) is a commonly antifibrinolytic agent in cardiac surgeries with cardiopulmonary bypass (CPB), however, there is concern that it might increase incidence of stroke after cardiac surgery. In this retrospective study, we investigated whether TXA usage could increase postoperative stroke in cardiac surgery.

Methods

A retrospective study was conducted from January 1, 2010, to December 31, 2015, in 2,016 patients undergoing cardiac surgery, 664 patients received intravenous TXA infusion and 1,352 patients did not receive any antifibrinolytic agent. Univariate and propensity-weighted multivariate regression analysis were applied for data analysis.

Results

Intr

SUBMITTER: Zhou ZF 

PROVIDER: S-EPMC5446127 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature