Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

ABSTRACT: Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure and hypertension in people of African ancestry, we performed both single and multiple-trait genome-wide association analyses. We analyzed 21 genome-wide association studies comprised of 31,968 individuals of African ancestry, and validated our results with additional 54,395 individuals from multi-ethnic studies. These analyses identified nine loci with eleven independent variants which reached genome-wide significance (P < 1.25×10-8) for either systolic and diastolic blood pressure, hypertension, or

SUBMITTER: Liang J 

PROVIDER: S-EPMC5446189 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature