20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (G_q) to Affect Vascular Function and Trigger Hypertension.

ABSTRACT:

Rationale

20-Hydroxyeicosatetraenoic acid (20-HETE), one of the principle cytochrome P450 eicosanoids, is a potent vasoactive lipid whose vascular effects include stimulation of smooth muscle contractility, migration, and proliferation, as well as endothelial cell dysfunction and inflammation. Increased levels of 20-HETE in experimental animals and in humans are associated with hypertension, stroke, myocardial infarction, and vascular diseases.

Objective

To date, a receptor/binding site for 20-HETE has been implicated based on the use of specific agonists and antagonists. The present study was undertaken to identify a receptor to which 20-HETE binds and through which it activates a signaling cascade that culminates in many of the functional outcomes attributed to 20-HETE in

SUBMITTER: Garcia V 

PROVIDER: S-EPMC5446268 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature