AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling.

ABSTRACT:

Rationale

Angiogenesis improves perfusion to the ischemic tissue after acute vascular obstruction. Angiogenesis in pathophysiological settings reactivates signaling pathways involved in developmental angiogenesis. We showed previously that AIBP (apolipoprotein A-I [apoA-I]-binding protein)-regulated cholesterol efflux in endothelial cells controls zebra fish embryonic angiogenesis.

Objective

This study is to determine whether loss of AIBP affects angiogenesis in mice during development and under pathological conditions and to explore the underlying molecular mechanism.

Methods and results

In this article, we report the generation of AIBP knockout (Apoa1bp^-/-) mice, which are characterized of accelerated postnatal retinal angiogenesis. Mechanistically

SUBMITTER: Mao R 

PROVIDER: S-EPMC5446274 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature