Mesenchymal Stem Cells Modulate Differentiation of Myeloid Progenitor Cells During Inflammation.

ABSTRACT: Mesenchymal stem cells (MSCs) possess distinct immunomodulatory properties and have tremendous potential for use in therapeutic applications in various inflammatory diseases. MSCs have been shown to regulate pathogenic functions of mature myeloid inflammatory cells, such as macrophages and neutrophils. Intriguingly, the capacity of MSCs to modulate differentiation of myeloid progenitors (MPs) to mature inflammatory cells remains unknown to date. Here, we report the novel finding that MSCs inhibit the expression of differentiation markers on MPs under inflammatory conditions. We demonstrate that the inhibitory effect of MSCs is dependent on direct cell-cell contact and that this intercellular contact is mediated through interaction of CD200 expressed by MSCs and CD200R1 expressed by MPs. Fu

SUBMITTER: Amouzegar A 

PROVIDER: S-EPMC5446294 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature