Kernel machine score test for pathway analysis in the presence of semi-competing risks.

ABSTRACT: In cancer studies, patients often experience two different types of events: a non-terminal event such as recurrence or metastasis, and a terminal event such as cancer-specific death. Identifying pathways and networks of genes associated with one or both of these events is an important step in understanding disease development and targeting new biological processes for potential intervention. These correlated outcomes are commonly dealt with by modeling progression-free survival, where the event time is the minimum between the times of recurrence and death. However, identifying pathways only associated with progression-free survival may miss out on pathways that affect time to recurrence but not death, or vice versa. We propose a combined testing procedure for a pathway's association with b

SUBMITTER: Neykov M 

PROVIDER: S-EPMC5446310 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature