Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice.

ABSTRACT:

Background and purpose

Excessive inflammation in sepsis causes microvascular thrombosis and thrombocytopenia associated with organ dysfunction and high mortality. The present studies aimed to investigate whether inhibition of dipeptidyl peptidase-4 (DPP-4) and supplementation with glucagon-like peptide-1 (GLP-1) receptor agonists improved endotoxaemia-associated microvascular thrombosis via immunomodulatory effects.

Experimental approach

Endotoxaemia was induced in C57BL/6J mice by a single injection of LPS (17.5 mg kg^-1 for survival and 10 mg kg^-1 for all other studies). For survival studies, treatment was started 6 h after LPS injection. For all other studies, drugs were injected 48 h before LPS treatment.

Key results

Mice treated with LPS alon

SUBMITTER: Steven S 

PROVIDER: S-EPMC5446582 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature