Constitutive androstane receptor regulates the intestinal mucosal response to injury.

ABSTRACT:

Background and purpose

The pathogenesis of the inflammatory bowel diseases (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), involves aberrant interactions between a genetically susceptible individual, their microbiota and environmental factors. Alterations in xenobiotic receptor expression and function are associated with increased risk for IBD. Here, we have assessed the role of the constitutive androstane receptor (CAR), a xenobiotic receptor closely related to the pregnane X receptor, in the regulation of intestinal mucosal homeostasis.

Experimental approach

CAR expression was assessed in intestinal mucosal biopsies obtained from CD and UC patients, and in C57/Bl6 mice exposed to dextran sulphate sodium (DSS; 3.5% w/v in drinking water) to evoke intesti

SUBMITTER: Hudson GM 

PROVIDER: S-EPMC5446585 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature