GLADIATOR: a global approach for elucidating disease modules.

ABSTRACT:

Background

Understanding the genetic basis of disease is an important challenge in biology and medicine. The observation that disease-related proteins often interact with one another has motivated numerous network-based approaches for deciphering disease mechanisms. In particular, protein-protein interaction networks were successfully used to illuminate disease modules, i.e., interacting proteins working in concert to drive a disease. The identification of these modules can further our understanding of disease mechanisms.

Methods

We devised a global method for the prediction of multiple disease modules simultaneously named GLADIATOR (GLobal Approach for DIsease AssociaTed mOdule Reconstruction). GLADIATOR relies on a gold-standard disease phenotypic similarity to obtain a pa

SUBMITTER: Silberberg Y 

PROVIDER: S-EPMC5446740 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature