Breaking RAD: an evaluation of the utility of restriction site-associated DNA sequencing for genome scans of adaptation.

ABSTRACT: Understanding how and why populations evolve is of fundamental importance to molecular ecology. Restriction site-associated DNA sequencing (RADseq), a popular reduced representation method, has ushered in a new era of genome-scale research for assessing population structure, hybridization, demographic history, phylogeography and migration. RADseq has also been widely used to conduct genome scans to detect loci involved in adaptive divergence among natural populations. Here, we examine the capacity of those RADseq-based genome scan studies to detect loci involved in local adaptation. To understand what proportion of the genome is missed by RADseq studies, we developed a simple model using different numbers of RAD-tags, genome sizes and extents of linkage disequilibrium (length of haplotype

SUBMITTER: Lowry DB 

PROVIDER: S-EPMC5446919 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature